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Polyunsaturated fatty acids undergo nonenzymatic peroxidation when oxygen radicals generated by mitochondrial ROS production remove a hydrogen atom from the lipid, resulting in a lipid radical that can propagate to generate more peroxyl/alkoxyl radicals and hydroperoxide [83]
Another unique feature is that the body produces glutathione inside cells, where it helps protect DNA, proteins, cell membranes, and mitochondria from oxidative damage
Glucose-6-phosphate produced from glucose can be oxidized by glucose-6-phosphate dehydrogenase to generate NADPH and ribose-5-phosphate, necessary for nucleotide synthesis
Researchers studying inflammatory cascades or cytokine storm models may find KLOWs broader mechanism profile better suited to their experimental design
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